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Changes in level of endogenous peptides of the blood serum in the process of aging were investigated in dogs. A decrease in concentration of atrial natriuretic peptide, beta-endorphin, bradykinin, and opioid peptide from blood serum was recorded in elderly dogs. Content of tachykinins in blood serum was shown to increase in dogs with spontaneous hypertension and in those which were offered an atherogenic diet. It is assumed that decrease in level of peptides studied and decrease in functional activity of the nervous system in old animals reflect a deranged regulation of the cardiovascular system and endocrine glands in old age.Extensive subretinal neovascularization associated with retinitis pigmentosa.
A 3-year-old girl with retinitis pigmentosa and normal-sized optic disc was observed for 6 years. She developed vitreous hemorrhage and neovascular glaucoma. Extensive subretinal neovascularization with attenuated retinal vessels and patchy retinal pigment epithelial atrophy was noted. This is the first report of such features in this disease./*
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